At about 10.45pm officers were called to an address in Crescent Drive in Little Hulton.
Police found damage to a window at the front of the house and evidence that a gun had been fired.
Officers are now searching for two men in relation to the incident. Both were wearing tracksuits with hooded tops, one of which was blue.
It is understood one woman was in the house at the time of the incident. She was unhurt.
Det Insp Carl Gilbert said: “We are keen to speak to anyone who might have seen two men matching the description in the area at the time.
“If you believe you have seen anything that may assist us with our investigation, please contact us as soon as possible.”
Anyone with any information about the incident is asked to call police on 101 or independent charity Crimestoppers on 0800 555 111.